Protein Details: Gap junction alpha-1 protein

Protein ID

ICDB_Pro_0418

Protein Name

Gap junction alpha-1 protein

Gene Name

Gja1; Cxn-43

Organism

Mus musculus (Mouse)

Length

382 amino acids

AlphaFoldDB

AF-P23242-F1-model_v4.pdb

Function

Sequence

MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDGVNVEMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSVFEVAFLLIQWYIYGFSLSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVKDRVKGRSDPYHATTGPLSPSKDCGSPKYAYFNGCSSPTAPLSPMSPPGYKLVTGDRNNSSCRNYNKQASEQNWANYSAEQNRMGQAGSTISNSHAQPFDFPDDSQNAKKVAAGHELQPLAIVDQRPSSRASSRASSRPRPDDLEI

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Expressed in heart; non-sensory epithelial cells; and in fibrocytes of the spiral ligament and the spiral limbus. Expressed in bladder smooth muscle cells (at protein level). Expressed in astrocytes (at protein level) (PubMed:15213231). Expressed in astrocytes (at protein level) (PubMed:15213231). Expressed in astrocytes (at protein level) (PubMed:15213231).

DOI ID

10.1016/s0021-9258(18)92924-8; 10.1016/0012-1606(91)90452-9; 10.1083/jcb.117.6.1299; 10.1016/0378-1119(93)90419-4; 10.1126/science.1112014; 10.1101/gr.2596504; 10.1016/0022-2828(90)90061-6; 10.1093/hmg/10.25.2945; 10.1074/jbc.m404073200; 10.1074/jbc.m403952200; 10.1021/bi048306w; 10.1074/mcp.m600046-mcp200; 10.1074/jbc.m709288200; 10.1021/pr0701254; 10.1016/j.cell.2010.12.001; 10.1093/hmg/ddp490; 10.1074/jbc.m110.170753; 10.1161/atvbaha.110.215939; 10.1038/ncomms1812; 10.1038/ncomms9391; 10.3389/fncel.2017.00122

RefSeq

NP_034418.1